This paper describes developed and validated thin layer liquid chromatography (TLC) method for the simultaneous estimation of Rosuvastatin calcium and Telmisartan in a combined dosage form. Rosuvastatin calcium and Telmisartan were determined by High Performance Thin Layer chromatography method (HPTLC) in tablet dosage form. The method was carried out in TLC Precoated silica gel on aluminum plate 60 F 254, (10 cm ×10 cm, prewashed by methanol and activated at 60° C for 5 min prior to chromatography). The solvent system wasToluene: Methanol: Glacial acetic acid in the proportion of 8.5:1.5:0.1, (v/v/v/v) with Rf Value for rosuvastatin calcium and telmisartan was 0.29 and 0.37 respectively. The linearity regression analysis for calibration showed 0.996 and 0.998 for rosuvastatin calcium and telmisartan with respect to peak area and height in the concentration range of 4- 20ng/band and 16-80ng/band respectively. The method developed can be used for routine analysis of drugs content in tablet dosage form. The method was validated as per ICH (International Conference on Harmonisation) Guidelines, proving its utility in estimation of Rosuvastatin calcium and Telmisartan in combined dosage form.
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